The specific degradation of fibrin (ie, fibrinolysis) is the reactive mechanism responding to the formation of fibrin. Plasmin is the fibrinolytic enzyme derived from inactive plasminogen. Plasminogen is converted into plasmin by plasminogen activators. The main plasminogen activators are tissue plasminogen activator (tPA) and pro-urokinase, which is activated into urokinase (UK) by, among others, the contact system of coagulation.
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In the bloodstream, plasmin is rapidly and specifically neutralized by alpha-2-antiplasmin, thereby restricting its fibrinogenolytic activity and localizes the fibrinolysis on the fibrin clot. On the fibrin clot, plasmin degrades fibrin into various products (ie, D-dimers). Antibodies specific for these products, which do not recognize fibrinogen, have been developed. The presence of these various fibrin degradation products, among which D-dimer is the terminal product, is the proof that the fibrinolytic system is in action in response to coagulation activation.
Elevated D-dimer levels are found in association with disseminated intravascular coagulation (DIC), pulmonary embolism (PE), deep vein thrombosis (DVT), trauma, and bleeding. D-dimer may also be increased in association with pregnancy, liver disease, malignancy, inflammation, or a chronic hypercoagulable state.
EPDM is part of Dicor’s three-part roofing system that includes the roofing membrane, bonding adhesive and lap sealant.
Dicor EPDM:
- Is well suited for retrofit installations
- Flexes very well, making it fit snugly around corners and adhere readily to bonding agents
- Eliminates irritating roof rumble
- Requires less lifetime maintenance than competing roofing systems
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Our Installation Component Kit makes it easy for RVers and service centers to do their own repairs. Capture one 10 1 – raw workflow software. The kit contains everything necessary for an average RV roof installation — except for the roof membrane which is sold separately.
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Dicor EPDM is a product of Carlisle Syntec Incorporated, a leader in commercial roofing materials. Designed specifically for the RV industry, Carlisle membranes are the first choice of RV manufacturers. They have received the Energy Star rating for environmental efficiency and are backed by the industry’s only 12-year warranty. That’s added peace of mind!